Protective effect of Alhagi sparsifolia against acetaminophen-induced liver injury in mice
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چکیده
منابع مشابه
Protective effect of fucoidan against acetaminophen-induced liver injury.
Fucoidan, a sulfated polysaccharide extracted from various brown seaweeds, possesses a wide range of pharmacological properties. In this study, we investigated the protective effect of fucoidan on acetaminophen-induced acute liver injury in rats. Liver injury was induced by administration of acetaminophen (800 mg/kg, i.p.) and fucoidan was administered (100 mg kg, p.o.) 2 h before and after ace...
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OBJECTIVES The hepatotoxicity of acetaminophen is not a result of the parent compound but is mediated by its reactive metabolite N-acetyl-p-benzoquinone imine. Cytochrome P4502E1 (CYP2E1) is the principal enzyme of this biotransformation, which accounts for approximately 52% of the bioactivation in human microsomes. Recently, chlormethiazole a sedative drug, is reported to be an efficient inhib...
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Introduction: In many cultures fasting is recommended as a way to protect and promote health. However, there are few studies on the effects of fasting on organ function and resistance to toxic agents such as drugs. This study was conducted to investigate the effect of short-term periodic fasting on the acetaminophen hepatotoxic effects in mice. Methods: In this...
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The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl-2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated controlgroup (C) (n=6), I/R group (...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2018
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v17i4.11